Principal Investigator

Prof. Yu Xia
Principal Investigator

Prof. Yu Xia

xiayu@mail.tsinghua.edu.cn

Yu Xia earned her B.S. (1999) in Chemistry from Lanzhou University, China, M.S. (2002) from Shanghai Institute of Material Medical, CASs, China, and Ph.D. (2006) under the supervision of Professor Scott A. McLuckey from Purdue University, USA.  After postdoctoral training with Professor Graham R. Cooks at Purdue, Dr. Xia took positions as an Assistant and Associate Professor at the Department of Chemistry, Purdue University (2009-2017). She joined Tsinghua University as a Professor of the Department of Chemistry in 2016. She was the recipient of the ASMS Research Award and her research has been supported by the Distinguished Young Scholars and the Outstanding Young Scholars Program from the National Natural Science Foundation of China. She served as Secretary of the Board of Directors of the American Society for Mass Spectrometry from 2015 to 2017. She currently serves as Vice Chair of the Organic Analysis Committee of the Chinese Chemical Society, Vice President of the International Lipidomics Society (ILS), Asia-Pacific Regional Reprsentative, Exuctive Board of the International Mass Spectrometry Foundation (IMSF), Editor of Journal of Mass Spectrometry, and Editorial Board Member of Journal of Lipid Research. She teaches multiple undergraduate and graduate courses and has received the First Prize for Outstanding Class Advisor and the Excellent Mentor Award at Tsinghua University.

ORCID: https://orcid.org/0000-0001-8694-9900

瑕瑜课题组-成员 Xia Lab-成员

Biological mass spectrometry isomer analysis radical chemistry lipidomics

Postdoctoral Researcher

Dr. Haiyue Hou
Postdoctoral Researcher

Dr. Haiyue Hou

hy-hou@mail.tsinghua.edu.cn

2016.9–2020.6 B.S. College of Chemistry, Beijing University of Chemical Technology

2020.9–2025.6 Ph.D. College of Chemistry, Beijing University of Chemical Technology

2025.7–now, Postdoc, Department of Chemistry, Tsinghua University


Awards

2025 Outstanding Graduate Student of Beijing City

2024 Graduate Fellowship of BUCT


Representative Work:

· Haiyue Hou, Shuya Yang, Xuexin Yang, Zhenxia Du*, et al. Comprehensive profiling and development of a collision cross section database for milk oligosaccharides via orthogonal UPLC-cyclic ion mobility-mass spectrometry system. Food Chem., 2025, 480.

· Haiyue Hou, Shuya Yang, Xuexin Yang, Zhenxia Du*, et al. Sensitive and high-throughput isomer-specific analysis of human milk oligosaccharides using UPLC-MS/MS and its application to secretor status assignment. Carbohydr. Polym., 2025, 352.

· Haiyue Hou, Mengyu Wang, Shuya Yang, Zhenxia Du*, et al. Evaluation of Prebiotic Glycan Composition in Human Milk and Infant Formula: Profile of Galacto-Oligosaccharides and Absolute Quantification of Major Milk Oligosaccharides by UPLC-Cyclic IM-MS and UPLC-MS/MS. J. Agric. Food Chem., 2024.


Research interests: 

The selective enrichment and analysis of glycosphingolipids; 

Isomer-resolved charaterization of human milk oligosaccharides (Ph.D)


瑕瑜课题组-成员 Xia Lab-成员

High-throughput sphingolipidomics and metabolism Isomer-resolved analysis of human milk oligosaccharides (PhD)

Graduate Students

Lipeng Qiao
Graduate Students

Lipeng Qiao

qlp22@mails.tsinghua.edu.cn

2018.9-2022.6 B.S. College of Chemistry, Chemical Engineering and Materials Science, Soochow University

2022.9-now  Department of Chemistry, Tsinghua University

瑕瑜课题组-成员 Xia Lab-成员

Isomer-resolved MS/MS Multiplexed quantitation of lipids at multiple structural levels
Wei Wan
Graduate Students

Wei Wan

wan-w23@mails.tsinghua.edu.cn

2019.9-2023.6 B.S. College of Chemistry, Sichuan University

2023.9-now  Department of Chemistry, Tsinghua University

瑕瑜课题组-成员 Xia Lab-成员

Lipid-protein interactions
Jitong Wang
Graduate Students

Jitong Wang

wangjt23@mails.tsinghua.edu.cn

2019.8-2023.6 B.S. in Chemical biology, Department of Chemistry, Tsinghua University

2023.9-now  Department of Chemistry, Tsinghua University 


瑕瑜课题组-成员 Xia Lab-成员

Biological lipidome profiling at detailed structure level
Tengyuan Miao
Graduate Students

Tengyuan Miao

mty24@mails.tsinghua.edu.cn

2020.8-2024.6 B.S. College of Chemistry and Chemical Engineering, Hunan University

2024.8-now Department of Chemistry, Tsinghua University

瑕瑜课题组-成员 Xia Lab-成员

clinical analysis
Zhihui Huang
Graduate Students

Zhihui Huang

huangzhi24@mails.tsinghua.edu.cn

2020.09 – 2024.06 B.S. College of Chemistry and Molecular Sciences, Wuhan University

2025.08 – now Department of Chemistry, Tsinghua University

Award:

2024:Tsinghua University Future Scholar Fellowship for Doctoral Students

2025:Second-Class Prize for Comprehensive Excellence

Representative Work:

· Yongyi Li, Qian An, Zhihui Huang, et al. Surface Plasmon Polariton Enable Reaction-Specific Energy Transduction for Molecular Ionization. Laser & Photonics Reviews. 2026.  

· Zhongxian Li, Liwei Wang,  Zhihui Huang, et al. Cross-Double Deoxygenative Carbon−Carbon Bond Formationbetween Benzyl Benzoates and Allylic Alcohols. ACS Catal. 2024, 14, 12, 9496–9504.

瑕瑜课题组-成员 Xia Lab-成员

High-throughput lipid quantification Lipid biology
Yongle Chen
Graduate Students

Yongle Chen

chenyongle25@mails.tsinghua.edu.cn

2016.9-2020.6 B.S.  West China School of Pharmacy, Sichuan University

2020.9-2023.6 M.S. Academy of Military Medical Sciences - National Center for Protein Sciences (Beijing)

2023.10-now: Department of Chemistry, Tsinghua University


瑕瑜课题组-成员 Xia Lab-成员

Organelle Lipidomics Live-cell PB reaction
Weishen Zhou
Graduate Students

Weishen Zhou

zws25@mails.tsinghua.edu.cn

2021.8-2025.6  B.S.  College of Chemistry, JiLin University

2025.8-now  Department of Chemistry, Tsinghua University

Representative Work:

· Weishen Zhou, Songrui Li, Hetong Wang, Huifeng Zhang, Qiong Jia*. Novel zinc nanoclusters based ratiometric fluorescence sensing strategy for sensitive detection of thiram. Food Chem. 2026, 505, 147957.

· Zhou Weishen, Jia Jiahao, Mo Kangqiang, Xue Yingke, Li Songrui, Jia Qiong*. Application Progress of Metal Nanoclusters in Detection of Pesticides. Chin. J. Anal. Chem., 2024, 52, 460-468.

瑕瑜课题组-成员 Xia Lab-成员

sphingolipidome low-abundence glycosphingolipids functional glycosphingolipids
Minmin Hu
Graduate Students

Minmin Hu

min20000908@163.com

2018.9-2022.6 B.S. China University of Mining & Technology, Beijing

2022.9-2025.6 M.S. Beijing Normal University

2026.4-now Department of Chemistry, Tsinghua University

Representative Work:

C.Yang, M.Hu, C.Hu, X.Mi, S.Luo. Visible Light Promoted de Mayo Type Reaction of Bicyclo[1.1.0]butanes. Chem. Eur. J.2024, 30, e202402965.

J.Gao, M.Hu, X.Mi. Transition-Metal-Free Direct α-Arylation of Weinreb-type Amides with Arylboronic Acids through Aza-oxyallyl Cation Intermediates. J. Org. Chem. 2024, 89, 18, 13730–13734.


瑕瑜课题组-成员 Xia Lab-成员

Photocatalysis Radical Chemistry Structural Lipidomics

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