Our Team

2022.9 – 2026.6 B.S. College of Chemistry, Jilin University

2026.8 – now Department of Chemistry, Tsinghua University

Awards

2026 Tsinghua University Future Scholars Scholarship

2017.9–2021.7 B.S., College of Chemistry and Chemical Engineering, Nanjing University

2021.8–2026.10 Ph.D., Department of Chemistry, Tsinghua University

Awards:

2026, Second Class Comprehensive Excellence Scholarship (Tsinghua Friends – Chengde Outstanding Talent Scholarship)

2024, Second Class Comprehensive Excellence Scholarship (Tsinghua Friends – Shanghai Huayi Scholarship)

2025, Second Class Comprehensive Excellence Scholarship (Tsinghua Friends – Mianyang Science and Technology City Talent Scholarship)

Representative work:

· Yichun Wang, Yu Xia*, Deep profiling of plasmalogens by coupling the Paternò–Büchi derivatization with tandem mass spectrometry. Anal. Bioanal. Chem. 2024, 416(19): 4397-4407.

· Yichun Wang, Gaoge Sun, Hang Yin, Yu Xia*, Deep profiling reveals coordinated remodeling of ganglioside metabolism in MCF-7 breast cancer cell line. Chem. Sci. 2026, 17: 6488-6499.

· Yichun Wang, Yu Xia*, Deep profiling of porcine brain gangliosides enabled by TiO2 magnetic nanoparticle-based enrichment and advanced lipidomic analysis. Analyst, 2026, 151(11): 3081-3090.

· Zidan Wang, Yichun Wang, Yu Xia*, Multi-structural profiling of neutral glycosphingolipids using selective enrichment and the Paternò–Büchi derivatization, Methods Enzymol. 2026: 357-378.

· Shan-Le Wang, Kui Xiao, Yichun Wang, Yu Xia, Liang Zhao*, Single-atom synergy of luminescence and catalytic stability in silver-encapsulated gold nanoclusters. J. Am. Chem. Soc. 2026, 148(22): 22857-22866.

Research interests: 

PhD: Deep profiling and turover analysis of gangliosides via selective enrichment and tandem mass sepctrometry

2016.9-2020.6 B.S. Cuiying Honor College, Lanzhou University

2020.9-2026.6 Ph.D. Department of chemistry, Tsinghua University

Award：

2022 Outstanding Teaching Assistant

2024 Second-class Comprehensive Excellence Scholarship.

2025 First-class Comprehensive Excellence Scholarship

2025 First Prize in Oral Presentation at Doctoral Forum

Representative Work：

· Keting Zhou and Yu Xia*, High-Coverage Disulfide Mapping Enabled by Programmable Disulfide-Ene Reaction Integrated onto a Bottom-Up Protein Analysis Workflow. Anal. Chem. 2024, 96, 43, 17396–17404

· Keting Zhou, Xiaoyue Yang, Hanlin Ren, Yu Xia*, Visible-Light-Induced Disulfide Bond Reduction in Peptides and Proteins. J. Phys. Chem. A  2025, 129, 32, 7421–7428

· Keting Zhou and Yu Xia*, Bottom–Up Protein Analysis Workflow for Simultaneous Characterization of Payloads, Disulfide Bonds, and Free Thiols in Antibody–Drug Conjugates. Anal. Chem. 2025, 97, 51, 28132–28138

Position:

2015.9–2019.6 B.S.  Department of Chemistry, Fudan University

2019.9-2026.6  PhD.  Department of Chemistry, Tsinghua University

Awards

2022 First-Class Comprehensive Scholarship of Tsinghua University

Representative Publications

· Jian R J, Zhao X, Lin Q H, Xia Y. Profiling of branched‑chain fatty acids via nitroxide radical‑directed dissociation integrated on an LC‑MS/MS workflow. Analyst, 2022, 147: 2115‑2123.

· Jian R J, Wang S Z, Qiao L P, Zhao X*, Xia Y*. Profiling of Low‑Abundance Branched‑Chain Fatty Acids via Radical Directed Dissociation Tandem Mass Spectrometry. J Am Soc Mass Spectrom, 2026, 37: 782‑789.

· Jian R J, Xia Y*. Research progress of free radical chemistry-tandem mass spectrometry for fine structure analysis of lipids. Journal of Chinese Mass Spectrometry Society, 2024, 45(1): 57-68.

2015.9-2019.6 B.S. Cuiying Honor College, Lanzhou University

2019.8-2025.6 PhD. Department of Chemistry, Tsinghua University

Representative Works：

· Hengxue Shi, Zhenshu Tan, Xiangyu Guo, Hanlin Ren, Shengzhuo Wang, Yu Xia*. Visible-Light Paternò–Büchi Reaction for Lipidomic Profiling at Detailed Structure Levels. Anal. Chem., 2023, 95, 5117–5125.

· Hengxue Shi, Yu Xia*. Shotgun Lipidomic Profiling of Sebum Lipids via Photocatalyzed Paternò–Büchi Reaction and Ion Mobility-Mass Spectrometry. Anal. Chem., 2024, 96, 5589–5597.

· Hengxue Shi, Huijiao Bai, Haiteng Deng, Yu Xia*. Revealing Acyl Chain Selectivity of Cis-to-Trans Isomerase through Profiling  of C=C Geometry and Location Isomers of Bacterial Lipids. Anal. Chem., 2025, 97, 10378–10387.

Position：

BeOne Medicines Ltd.（Suzhou, China）